Gut health and obesity

Research is revealing connections between the gut microbiome, inflammation and obesity.

It is well known that metabolic disease can occur when the human body’s processes for storing and using energy become disturbed. The gut microbiome plays an important role in these processes. For example, studies have investigated the mechanistic interactions between the gut microbiome and the host in the balance of energy metabolism.

Explore the research articles listed below to learn more about these insights and uncover further links between gut microbiome and obesity.

Science digests and blogs

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Gut microbiota of infants predicts obesity in children

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New link between gut bacteria and obesity

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How altered gut microbes cause obesity

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Gut bacteria play a role in long-term weight gain

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Gut flora dictates how much weight we can lose

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Gut microbes contribute to recurrent 'yo-yo' obesity

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Gut fungi might be linked to obesity and inflammatory bowel disorders

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Microbes, not food restriction, could be the key to our most effective treatment for obesity

Academic

Boulangé, C. L., Neves, A. L., Chilloux, J., Nicholson, J. K. & Dumas, M.-E.
Impact of the gut microbiota on inflammation, obesity, and metabolic disease.
Genome Med. 8, 42 (2016). Doi: 10.1186/s13073-016-0303-2

Castaner, O. et al.
The gut microbiome profile in obesity: a systematic review.
International Journal of Endocrinology 2018, 4095789 (2018). Doi: 10.1155/2018/4095789

Dao, M. C. et al.
Akkermansia muciniphila and improved metabolic health during a dietary intervention in obesity: relationship with gut microbiome richness and ecology.
Gut 65: 426-436. (2016). Doi: 10.1136/gutjnl-2014-308778

Liu R, et al.
Gut microbiome and serum metabolome alterations in obesity and after weight-loss intervention.
Nature Medicine 23(7): 859-868. (2017). Doi: 10.1038/nm.4358

Menni, C. et al.
Gut microbiome diversity and high-fibre intake are related to lower long-term weight gain.
Int. J. Obes. (Lond.) 41: 1099-1105. (2017). Doi: 10.1038/ijo.2017.66

Ottosson F, et al.
Connection between BMI-related plasma metabolite profile and gut microbiota.
The Journal of Clinical Endocrinology & Metabolism 103(4): 1491–1501. (2018). Doi: 10.1210/jc.2017-02114

Perry, R. J. et al.
Acetate mediates a microbiome–brain–β-cell axis to promote metabolic syndrome.
Nature 534, 213 (2016). Doi: 10.1038/nature18309

Serena C, et al.
Elevated circulating levels of succinate in human obesity are linked to specific gut microbiota.
The ISME Journal 12(7): 1642-1657. (2018). Doi: 10.1038/s41396-018-0068-2

Thaiss, C. A. et al.
Persistent microbiome alterations modulate the rate of post-dieting weight regain.
Nature 540, 544 (2016). Doi: 10.1038/nature20796