Gut health and inflammatory bowel diseases

Research shows a number of bowel diseases linked to inflammation have been correlated with changes in the gut microbiome.

Recent advances in technology have led to a richer understanding of the role the gut microbiome plays in inflammatory bowel diseases, such as Crohn’s disease, Irritable Bowel Syndrome, Ulcerative Colitis and colorectal cancers. For example, functional gene counts and species diversity are now known to be considerably lower in patients with Crohn’s disease.

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Explore the research articles listed below to learn more about these insights and uncover further links between gut microbiome and inflammatory diseases of the bowel.

Science digests and blogs

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Microbiome profiling reveals associations with ulcerative colitis severity, treatment


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Strawberries may reduce gut inflammation


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Researchers find connection between viruses and inflammatory bowel disease


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Chance discovery links inflammatory bowel disease with common bacterial gut toxin


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Engineering the gut microbiome with 'good' bacteria may help treat Crohn's disease


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Microbiomes more in flux in patients with inflammatory bowel disease


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Gut fungus suspected in Crohn’s Disease


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Gut microbiomes may hold clues to IBD treatment's likelihood of success


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Gut microbiome analysis could help with IBD treatments

Academic

Halfvarson J, et al.
Dynamics of the human gut microbiome in inflammatory bowel disease.
Nature Microbiology 2, 17004 (2017). Doi: 10.1038/nmicrobiol.2017.4

He, Q. et al.
Two distinct metacommunities characterize the gut microbiota in Crohn’s disease patients.
GigaScience 6, 7 (2017). Doi: 10.1093/gigascience/gix050

Machiels, K. et al.
A decrease of the butyrate-producing species Roseburia hominis and Faecalibacterium prausnitzii defines dysbiosis in patients with ulcerative colitis.
Gut 63(8): 1275-1283. (2014). Doi: 10.1136/gutjnl-2013-304833

Matsuoka, K. & Kanai, T.
The gut microbiota and inflammatory bowel disease.
Semin. Immunopathol. 37(1): 47-55. (2015) . Doi: 10.1007/s00281-014-0454-4

McIlroy J, et al.
Review article: the gut microbiome in inflammatory bowel disease-avenues for microbial management.
Aliment Pharmacol Ther. 47(1): 26-42. (2018). Doi: 10.1111/apt.14384

Nishida A, et al.
Gut microbiota in the pathogenesis of inflammatory bowel disease.
Clinical Journal of Gastroenterology 11(1): 1-10. (2017). Doi: 10.1007/s12328-017-0813-5

Pascal, V. et al.
A microbial signature for Crohn’s disease.
Gut 66 (5): 813–822. (2017). Doi: 10.1136/gutjnl-2016-313235

Rapozo DC, Bernardazzi C, de Souza HS.
Diet and microbiota in inflammatory bowel disease: the gut in disharmony.
World J Gastroenterol. 23(12): 2124-2140. (2017). Doi: 10.3748/wjg.v23.i12.2124

Schirmer M, et al.
Dynamics of metatranscription in the inflammatory bowel disease gut microbiome.
Nature Microbiology 3(3): 337-346. (2018). Doi: 10.1038/s41564-017-0089-z

Zamani, S. et al.
Detection of enterotoxigenic Bacteroides fragilis in patients with ulcerative colitis.
Gut Pathog. 9, 53 (2017). Doi: 10.1186/s13099-017-0202-0