Gut health and central nervous system diseases

Research has associated changes in the gut microbiome with several neurodegenerative and central nervous system diseases, such as Alzheimer's and Parkinson's disease.

For example, it has emerged that patients with Alzheimer’s disease have a distinct microbiome composition and decreased microbial diversity compared to healthy individuals. Other recent studies have associated changes in the gut microbiome with Multiple Sclerosis, Amyloid Lateral Sclerosis and Parkinson’s.

Explore the research articles listed below to learn more about these insights and uncover further links between the gut microbiome and neurodegenerative diseases.

Science digests and blogs

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Does Parkinson’s begin in the gut?


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Advances along the gut-liver-brain axis in Alzheimer's disease?


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How the gut influences neurologic disease


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Study finds people with Alzheimer's disease have altered gut bacteria


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Gut-brain axis and neurodegenerative disorders


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Targeting gut bacteria may be the key to preventing Alzheimer's


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Altered gut microbiome could indicate Parkinson’s disease


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Gut microbes could help trigger multiple sclerosis


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How bacteria in the gut influence neurodegenerative disorders


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Human gut microbe may lead to treatment for multiple sclerosis

Academic

Brown, E.G., Tanner, C.M., and Goldman, S.M.
The microbiome in neurodegenerative disease.
Current Geriatrics Reports 7(2): 81-91. (2018). Doi: 10.1007/s13670-018-0240-6

Cova I, Priori A.
Diagnostic biomarkers for Parkinson's disease at a glance: where are we?.
Journal of Neural Transmission 125(10): 1417-1432. (2018). Doi: 10.1007/s00702-018-1910-4

Filosa S, Di Meo F, and Crispi S..
Polyphenols-gut microbiota interplay and brain neuromodulation.
Neural Regeneration Research 13(12): 2055-2059. (2018). Doi: 10.4103/1673-5374.241429

Heintz-Buschart, A. et al.
The nasal and gut microbiome in Parkinson’s disease and idiopathic rapid eye movement sleep behavior disorder.
Mov. Disord. 33(1): 88-98. (2018). Doi: 10.1002/mds.27105

Jangi, S. et al.
Alterations of the human gut microbiome in multiple sclerosis.
Nature Communications 7, 12015 (2016). Doi: 10.1038/ncomms12015

Lin L., Zheng L.J., and Zhang L.J.
Neuroinflammation, gut microbiome, and Alzheimer's disease.
Molecular Neurobiology 55(11): 8243-8250. (2018). Doi: 10.1007/s12035-018-0983-2

Mangalam, A. et al.
Human gut-derived commensal bacteria suppress CNS inflammatory and demyelinating disease.
Cell Reports 20(6): 1269-1277. (2017). Doi: 10.1016/j.celrep.2017.07.031

Mowry, E. M. and Glenn, J.D.
The Dynamics of the gut microbiome in Multiple sclerosis in relation to disease.
Neurologic Clinics 36(1): 185-196. (2018). Doi: 10.1016/j.ncl.2017.08.008

Sampson, T. R. et al.
Gut microbiota regulate motor deficits and neuroinflammation in a model of parkinson’s disease.
Cell 167(6): 1469-1480. (2016). Doi: 10.1016/j.cell.2016.11.018

Scheperjans, F. et al.
Gut microbiota are related to Parkinson’s disease and clinical phenotype.
Mov. Disord. 30(3): 350-358. (2015). Doi: 10.1002/mds.26069

Spielman L.J., Gibson D.L., Klegeris A.
Unhealthy gut, unhealthy brain: The role of the intestinal microbiota in neurodegenerative diseases.
Neurochemistry International 120: 149-163. (2018). Doi: 10.1016/j.neuint.2018.08.005

Vogt, N. M. et al.
Gut microbiome alterations in Alzheimer’s disease.
Sci. Rep. 7, 13537 (2017). Doi: 10.1038/s41598-017-13601-y

Yadav, Sudhir K et al.
Gut dysbiosis breaks immunological tolerance toward the central nervous system during young adulthood.
PNAS 114(44): E9318-E9327. (2017). Doi: 10.1073/pnas.1615715114